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Purushothama Rao Tata

Associate Professor of Cell Biology
Cell Biology

Overview


Lung regeneration
Lung stem cells
Cell plasticity
Organoid models
Lung Fibrosis
Single Cell Biology

Current Appointments & Affiliations


Associate Professor of Cell Biology · 2024 - Present Cell Biology, Basic Science Departments
Associate Professor in Medicine · 2024 - Present Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine
Member of the Duke Cancer Institute · 2016 - Present Duke Cancer Institute, Institutes and Centers
Affiliate of the Duke Regeneration Center · 2021 - Present Duke Regeneration Center, Basic Science Departments

In the News


Published November 15, 2023
Study Provides Clues to Developing Better Treatments for Lung Damage
Published July 20, 2022
Tata to Receive International Society for Regenerative Biology Rising Star Award
Published November 19, 2020
NIH-Directors blog- Mini-Lungs in a Lab Dish Mimic Early COVID-19 Infection

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Recent Publications


Novel Porcine Model Reveals Two Distinct LGR5 Cell Types during Lung Development and Homeostasis.

Journal Article Am J Respir Cell Mol Biol · May 2025 Cells expressing leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) play a pivotal role in homeostasis, repair, and regeneration in multiple organs, including skin and gastrointestinal tract, but little is known about their role in the lung ... Full text Link to item Cite

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage.

Journal Article Nat Methods · April 2025 The Human BioMolecular Atlas Program (HuBMAP) aims to construct a 3D Human Reference Atlas (HRA) of the healthy adult body. Experts from 20+ consortia collaborate to develop a Common Coordinate Framework (CCF), knowledge graphs and tools that describe the ... Full text Link to item Cite

Topology-driven discovery of transmembrane protein S-palmitoylation.

Journal Article J Biol Chem · March 2025 Protein S-palmitoylation is a reversible lipophilic posttranslational modification regulating diverse signaling pathways. Within transmembrane proteins (TMPs), S-palmitoylation is implicated in conditions from inflammatory disorders to respiratory viral in ... Full text Link to item Cite
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Recent Grants


Tau Mediates Microtubule and Mitochondrial Dynamics to Control Cellular Organization and Alveolar Epithelial Repair

ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 2024 - 2029

Alveolar injury and repair in Pompe Disease

ResearchCollaborator · Awarded by National Institutes of Health · 2025 - 2028

ETS-family Transcription Factor Mediated Control of Pulmonary Inflammation Induced by Influenza Viruses

ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2023 - 2028

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Education, Training & Certifications


University of Ulm (Germany) · 2011 Ph.D.
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